No drug/drug interaction studies have been conducted with Highly Purified Menotrophin (HUMOG) in humans. Although there is no controlled clinical experience, it is expected that the concomitant use of Highly Purified Menotrophin (HUMOG) and clomiphene citrate may enhance the follicular response. When using GnRH agonist for pituitary desensitization, a higher dose of Highly Purified Menotrophin (HUMOG) may be necessary to achieve adequate follicular response.